Genetic research examines how variations in DNA affect the system of human biomolecules—such as RNA and proteins—thereby affecting disease and an individual patient's response to drugs.

The advent of DNA sequencing methodology used to sequence the human genome—combined with advances in microarray technology, powerful computing hardware and software, and high-throughput analysis of biomolecules—has made it practical to initiate studies that may help us understand which genetic determinants cause or contribute to a disease or drug response.

Merck scientists have a strong commitment to understanding how genes work and how they are linked to diseases and drug treatments. For example, Merck scientists identified two genes in mice that could someday be targets for obesity prevention drugs.¹ Finding genetic signatures that can be influenced with drugs is very complex because, in addition to environmental and behavioral factors, many genes may contribute to each individual's obesity.

We collect genetic samples in Merck clinical trials and analyze data from such trials so we can apply new technologies to improve the development of new medicines and vaccines. The collection of samples represents the critical foundation of all clinical genetic research strategies. We obtain appropriate subject consent for use of the genetic samples in accordance with applicable domestic and international laws and regulations. We make every attempt to gain Ethics Committee approval for any broad consent on future research that may lead to rapid changes in the knowledge of human genetic associations to the human phenotype.

¹Nature Genetics 41, 415-423 (2009).